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vitamin B12 metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
nicotinic_acid_mononucleotide + 5,6-Dimethylbenzimidazole <=> alpha-ribazole_5''-phosphate + nicotinate + H+ 2.4.2.21 nicotinate-nucleotide---dimethylbenzimidazole phosphoribosyltransferase
2.4.2.55 nicotinate D-ribonucleotide:phenol phospho-D-ribosyltransferase
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cobalt-precorrin-5A + H2O <=> H+ + cobalt-precorrin-5B + acetaldehyde 3.7.1.12 cobalt-precorrin 5A hydrolase
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Hydrogenobyrinate + L-glutamine + ATP + H2O <=> H+ + L-glutamate + hydrogenobyrinic_acid_a,c-diamide + ADP + phosphate 6.3.5.11 cobyrinate a,c-diamide synthase
6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
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S-adenosyl-L-methionine + cobalt-precorrin-6B + H+ <=> cobalt-precorrin-7 + S-adenosyl-L-homocysteine + CO2 2.1.1.196 cobalt-precorrin-6B (C15)-methyltransferase [decarboxylating]
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S-adenosyl-L-methionine + precorrin-5 + H2O <=> H+ + precorrin-6A + S-adenosyl-L-homocysteine + acetate 2.1.1.152 precorrin-6A synthase (deacetylating)
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adenosylcobinamide + H2O <=> (R)-1-aminopropan-2-ol + adenosylcobyric_acid 3.5.1.90 adenosylcobinamide hydrolase
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S-adenosyl-L-methionine + cobalt-precorrin-3B <=> cobalt-precorrin-4 + S-adenosyl-L-homocysteine 2.1.1.131 precorrin-3B C17-methyltransferase
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FMNH2 + NADP+ <=> FMN + NADPH + H+ 1.18.1.2 ferredoxin---NADP+ reductase
1.5.1
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.39 FMN reductase [NAD(P)H]
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)
1.5.1.45 FAD reductase [NAD(P)H]
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cobalt-precorrin-6B + NAD+ <=> cobalt-precorrin-6A + NADH 1.3.1.106 cobalt-precorrin-6A reductase
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S-adenosyl-L-methionine + precorrin-2 <=> H+ + S-adenosyl-L-homocysteine + precorrin-3A 2.1.1.130 precorrin-2 C20-methyltransferase
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cobyrinate + L-glutamine + ATP + H2O <=> cob(II)yrinic_acid_a,c-diamide + L-glutamate + ADP + phosphate + H+ 6.3.5.11 cobyrinate a,c-diamide synthase
6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
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S-adenosyl-L-methionine + cobalt-sirohydrochlorin <=> H+ + S-adenosyl-L-homocysteine + cobalt-factor_III 2.1.1.151 cobalt-factor II C20-methyltransferase
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precorrin-2 + NAD+ <=> H+ + sirohydrochlorin + NADH 1.3.1.76 precorrin-2 dehydrogenase
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adenosylcobinamide-GDP + alpha-ribazole_5''-phosphate <=> adenosylcobalamin_5''-phosphate + GMP + H+ 2.7.8.26 adenosylcobinamide-GDP ribazoletransferase
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S-adenosyl-L-methionine + precorrin-3B <=> H+ + precorrin-4 + S-adenosyl-L-homocysteine 2.1.1.131 precorrin-3B C17-methyltransferase
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adenosylcobyrinic_acid_a,c-diamide + L-glutamine + ATP + H2O <=> H+ + L-glutamate + adenosylcobyric_acid + ADP + phosphate 6.3.5.10 adenosylcobyric acid synthase (glutamine-hydrolysing)
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S-adenosyl-L-methionine + precorrin-4 <=> precorrin-5 + S-adenosyl-L-homocysteine + H+ 2.1.1.133 precorrin-4 C11-methyltransferase
2.1.1.271 cobalt-precorrin-4 methyltransferase
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adenosylcobinamide-GDP + alpha-ribazole <=> H+ + adenosylcobalamin + GMP 2.7.8.26 adenosylcobinamide-GDP ribazoletransferase
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precorrin-3A + O2 + NADH + H+ <=> precorrin-3B + H2O + NAD+ 1.14.13.83 precorrin-3B synthase
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S-adenosyl-L-methionine + cobalt-precorrin-4 <=> S-adenosyl-L-homocysteine + cobalt-precorrin-5A + H+ 2.1.1.271 cobalt-precorrin-4 methyltransferase
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FMNH2 + O2 <=> 5,6-Dimethylbenzimidazole + D-erythrose_4-phosphate + other_product(s) 1.13.11.79 aerobic 5,6-dimethylbenzimidazole synthase
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S-adenosyl-L-methionine + Precorrin-6Y <=> precorrin-8X + S-adenosyl-L-homocysteine + CO2 + H+ 2.1.1.132 precorrin-6B C5,15-methyltransferase (decarboxylating)
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S-adenosyl-L-methionine + cobalt-precorrin-7 <=> cobalt-precorrin-8 + S-adenosyl-L-homocysteine 2.1.1.289 cobalt-precorrin-7 (C5)-methyltransferase
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S-adenosyl-L-methionine + cobalt-precorrin-5B <=> cobalt-precorrin-6A + S-adenosyl-L-homocysteine 2.1.1.195 cobalt-precorrin-5B (C1)-methyltransferase
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sirohydrochlorin + Co2+ <=> cobalt-sirohydrochlorin + H+ 4.99.1.3 sirohydrochlorin cobaltochelatase
4.99.1.4 sirohydrochlorin ferrochelatase
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adenosylcobalamin_5''-phosphate + H2O <=> adenosylcobalamin + phosphate 3.1.3.73 adenosylcobalamin/alpha-ribazole phosphatase
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hydrogenobyrinic_acid_a,c-diamide + Co2+ + ATP + H2O <=> H+ + cob(II)yrinic_acid_a,c-diamide + ADP + phosphate 6.6.1.2 cobaltochelatase
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Precorrin-6Y + NADP+ <=> precorrin-6A + NADPH + H+ 1.3.1.54 precorrin-6A reductase
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ATP + adenosylcobyric_acid + (R)-1-aminopropan-2-yl_phosphate <=> ADP + adenosylcobinamide_phosphate + phosphate + H+ 6.3.1.10 adenosylcobinamide-phosphate synthase
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alpha-ribazole_5''-phosphate + H2O <=> alpha-ribazole + phosphate 3.1.3.73 adenosylcobalamin/alpha-ribazole phosphatase
6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
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ATP + cob(II)yrinic_acid_a,c-diamide <=> tripolyphosphate + adenosylcobyrinic_acid_a,c-diamide 2.5.1.17 corrinoid adenosyltransferase
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cobalt-precorrin-8 <=> cobyrinate + H+ 5.4.99.60 cobalt-precorrin-8 methylmutase
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H+ + precorrin-8X <=> Hydrogenobyrinate 5.4.99.61 precorrin-8X methylmutase
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H+ + adenosylcobinamide_phosphate + GTP <=> adenosylcobinamide-GDP + diphosphate 2.7.1.156 adenosylcobinamide kinase
2.7.7.62 adenosylcobinamide-phosphate guanylyltransferase
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Visualization of the pathway